Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.24 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (early spermatids) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1777
Sealed predictions
- GLT6D1 in dopamine neurons, braak+0.47 (p 0.204) → +0.24 (p 0.533)receipt 1783
Swarm cases
receipt 1783: GLT6D1 in dopamine neurons, braak
- power
- full sample +0.33 (p 0.176, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.460, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.379, n 18). could be the mix.
- skeptic
- leave-one-out range +0.24 to +0.47, sign flips 0; without severely affected donors +0.33 (p 0.176, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GLT6D1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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