Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (peritubular myoid cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 14 Parkinson's papers of 3,731 | 0.64 |
| pathways Reactome | 4 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 9813
Sealed predictions
- GLI1 in dopamine neurons, braak-0.66 (p 0.053) → -0.52 (p 0.151)receipt 9819
Swarm cases
receipt 9819: GLI1 in dopamine neurons, braak
- power
- full sample -0.50 (p 0.034, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.51 (p 0.029, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.44, sign flips 0; without severely affected donors -0.50 (p 0.034, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GLI1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts