Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.06 (overall 0.04) | 0.06 |
| cell type Human Protein Atlas | group enriched outside the brain (late primary spermatocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 110 | 0.79 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6113
Sealed predictions
- GK2 in dopamine neurons, braak+0.77 (p 0.016) → +0.23 (p 0.560)receipt 6120
Swarm cases
receipt 6120: GK2 in dopamine neurons, braak
- power
- full sample +0.52 (p 0.026, n 18), 95% CI +0.07 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.52 (p 0.026, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.026, n 18). not the mix.
- skeptic
- leave-one-out range +0.47 to +0.66, sign flips 0; without severely affected donors +0.52 (p 0.026, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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