Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (ocular epithelial cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5004
Sealed predictions
- GJB4 in dopamine neurons, braak+0.11 (p 0.784) → -0.67 (p 0.050)receipt 5011
Swarm cases
receipt 5011: GJB4 in dopamine neurons, braak
- power
- full sample -0.31 (p 0.211, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.042, n 18). not the mix.
- skeptic
- leave-one-out range -0.44 to -0.22, sign flips 0; without severely affected donors -0.31 (p 0.211, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GJB4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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