Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (neuroendocrine cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 70 Parkinson's papers of 6,012 | 0.44 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6637
Sealed predictions
- GIP in dopamine neurons, braak-0.54 (p 0.130) → +0.16 (p 0.689)receipt 6643
Swarm cases
receipt 6643: GIP in dopamine neurons, braak
- power
- full sample -0.13 (p 0.597, n 18), 95% CI -0.57 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.455, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.355, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to -0.01, sign flips 0; without severely affected donors -0.13 (p 0.597, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GIP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts