parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.06 (overall 0.04)	0.06
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in kupffer cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 6143

GIMAP4 in microglia, braak+0.59 (p 0.098) → -0.08 (p 0.838)receipt 6150
GIMAP4 in dopamine neurons, braak-0.47 (p 0.204) → +0.19 (p 0.630)receipt 6151

receipt 6151: GIMAP4 in dopamine neurons, braak

power: full sample -0.12 (p 0.646, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.08 (p 0.761, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.915, n 18). could be the mix.
skeptic: leave-one-out range -0.26 to -0.03, sign flips 0; without severely affected donors -0.12 (p 0.646, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GIMAP4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6150: GIMAP4 in microglia, braak

power: full sample +0.20 (p 0.424, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.16 (p 0.532, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.38, sign flips 0; without severely affected donors +0.20 (p 0.424, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GIMAP4 in microglia.

case closed: nothing better to follow up.

loading the receipts