Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.48 (overall 0.41) | 0.48 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.24 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 45 Parkinson's papers of 110 | 0.50 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 0624
Sealed predictions
- GIGYF2 in dopamine neurons, braak+0.16 (p 0.685) → -0.15 (p 0.701)receipt 0630
Swarm cases
receipt 0630: GIGYF2 in dopamine neurons, braak
- power
- full sample +0.12 (p 0.627, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.603, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.671, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.24, sign flips 1; without severely affected donors +0.12 (p 0.627, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GIGYF2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts