Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: somatrem, pegvisomant, somapacitan +3 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 5 Parkinson's papers of 3,021 | 0.76 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6616
Sealed predictions
- GHR in dopamine neurons, braak+0.58 (p 0.102) → +0.68 (p 0.046)receipt 6623
Swarm cases
receipt 6623: GHR in dopamine neurons, braak
- power
- full sample +0.58 (p 0.011, n 18), 95% CI +0.16 to +0.83. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.60 (p 0.0080, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.61 (p 0.0075, n 18). not the mix.
- skeptic
- leave-one-out range +0.52 to +0.65, sign flips 0; without severely affected donors +0.58 (p 0.011, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GHR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts