parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.13 from other evidence	0.00
cell type Human Protein Atlas	cell type enriched in astrocytes (782 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	16 Parkinson's trials, 0 stopped	1.00
literature PubMed	968 Parkinson's papers of 25,420: well-trodden	0.10
pathways Reactome	2 pathways; mostly lysosome and autophagy	1.00

No case: the score is under the bar. Receipt 2275

receipt 2282: GFAP in dopamine neurons, braak

power: full sample -0.11 (p 0.664, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.621, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to -0.01, sign flips 0; without severely affected donors -0.11 (p 0.664, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GFAP in dopamine neurons.

case closed: nothing better to follow up.

receipt 2281: GFAP in astrocytes, braak

power: full sample +0.07 (p 0.774, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.696, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.04 to +0.20, sign flips 3; without severely affected donors +0.07 (p 0.774, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for GFAP in astrocytes.

case closed: nothing better to follow up.

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