Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (pancreatic islet cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 8 Parkinson's trials, 1 stopped | 0.90 |
| literature PubMed | 7 Parkinson's papers of 1,800 | 0.73 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2487
Sealed predictions
- GCG in dopamine neurons, braak-0.04 (p 0.909) → +0.50 (p 0.174)receipt 2494
Swarm cases
receipt 2494: GCG in dopamine neurons, braak
- power
- full sample +0.26 (p 0.294, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.26 (p 0.289, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.173, n 18). could be the mix.
- skeptic
- leave-one-out range +0.17 to +0.41, sign flips 0; without severely affected donors +0.26 (p 0.294, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GCG in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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