Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.54 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: acamprosate calcium, methohexital, remimazolam besylate +68 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 1 stopped | 0.20 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11464
Earlier readings: 2026-10-26 0.40; 2026-10-25 0.40; 2026-10-24 0.40; 2026-10-23 0.40.
Sealed predictions
- GABRP in dopamine neurons, braak+0.02 (p 0.965) → -0.24 (p 0.533)receipt 0599
- GABRP in dopamine neurons, resiliencen/a → n/areceipt 0150
- GABRP in dopamine neurons, braakn/a → n/areceipt 0149
Swarm cases
receipt 0599: GABRP in dopamine neurons, braak
- power
- full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.969, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.00 (p 0.990, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.09, sign flips 6; without severely affected donors -0.02 (p 0.942, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GABRP in dopamine neurons.
case closed: nothing better to follow up.
receipt 0150: GABRP in dopamine neurons, resilience
- cell type
- GABRP is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for GABRP in dopamine neurons.
case closed: nothing better to follow up.
receipt 0149: GABRP in dopamine neurons, braak
- cell type
- GABRP is not measured in dopamine neurons; looking elsewhere.
- cell type
- strongest in oligodendrocytes: +0.29 (p 0.0070, n 84). proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GABRP in dopamine neurons.
follow-up registered; not confirmed in ventral tegmental area.
follow-up GABRP · oligodendrocytes · braak: ventral tegmental area +0.06 p 0.572 (needs p < 0.0022)
Receipts
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