parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in cone photoreceptor cells	0.75
chemistry Open Targets	hard to drug	0.27
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 75	0.82
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 5710

receipt 5718: FMN1 in dopamine neurons, braak

power: full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.690, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.949, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.19, sign flips 4; without severely affected donors +0.07 (p 0.787, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FMN1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5717: FMN1 in microglia, braak

power: full sample +0.01 (p 0.962, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.09 (p 0.728, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.10 (p 0.696, n 18). could be the mix.
skeptic: leave-one-out range -0.12 to +0.11, sign flips 6; without severely affected donors +0.01 (p 0.962, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FMN1 in microglia.

case closed: nothing better to follow up.

loading the receipts