Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4362
Sealed predictions
- FKRP in dopamine neurons, braak-0.32 (p 0.407) → -0.25 (p 0.508)receipt 4370
Swarm cases
receipt 4370: FKRP in dopamine neurons, braak
- power
- full sample -0.30 (p 0.232, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.246, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.211, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.19, sign flips 0; without severely affected donors -0.30 (p 0.232, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.66 (p 0.0028, n 18) vs -0.30 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FKRP in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up FKRP · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.75 p 0.0077 (needs p < 4.5e-4)
Receipts
loading the receipts