Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (neutrophils) | 0.10 |
| chemistry Open Targets | compounds already reach it: tg100-801, xl-228, enmd-981693 +2 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 4,080 | 0.79 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10825
Sealed predictions
- FGR in dopamine neurons, braak+0.35 (p 0.362) → -0.62 (p 0.073)receipt 10831
Swarm cases
receipt 10831: FGR in dopamine neurons, braak
- power
- full sample -0.24 (p 0.346, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.302, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.125, n 18). could be the mix.
- skeptic
- leave-one-out range -0.35 to -0.13, sign flips 0; without severely affected donors -0.24 (p 0.346, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FGR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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