Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in astrocytes (528 nCPM) | 1.00 |
| chemistry Open Targets | compounds already reach it: fexagratinib, nintedanib esylate, hmpl-453 +22 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 3,985 | 0.76 |
| pathways Reactome | Reactome did not answer (Reactome: HTTP 429) | 0.00 |
No case: the score is under the bar. Receipt 7498
Sealed predictions
- FGFR3 in astrocytes, braak-0.26 (p 0.502) → -0.47 (p 0.204)receipt 7503
- FGFR3 in dopamine neurons, braak-0.88 (p 0.002) → +0.00 (p 1.000)receipt 7504
Swarm cases
receipt 7504: FGFR3 in dopamine neurons, braak
- power
- full sample -0.48 (p 0.043, n 18), 95% CI -0.77 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.47 (p 0.051, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.025, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.41, sign flips 0; without severely affected donors -0.48 (p 0.043, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FGFR3 in dopamine neurons.
case closed: nothing better to follow up.
receipt 7503: FGFR3 in astrocytes, braak
- power
- full sample -0.28 (p 0.265, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.33 (p 0.188, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.18 (p 0.471, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.265, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FGFR3 in astrocytes.
case closed: nothing better to follow up.
Receipts
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