parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.11 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	a small-molecule pocket: muparfostat	0.60
trials ClinicalTrials.gov	1 Parkinson's trial, 0 stopped	1.00
literature PubMed	75 Parkinson's papers of 9,496	0.43
pathways Reactome	48 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 2512

receipt 2520: FGF2 in dopamine neurons, braak

power: full sample -0.32 (p 0.198, n 18), 95% CI -0.68 to +0.17. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.32 (p 0.198, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.198, n 18). could be the mix.
skeptic: leave-one-out range -0.48 to -0.24, sign flips 0; without severely affected donors -0.32 (p 0.198, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FGF2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2519: FGF2 in astrocytes, braak

power: full sample -0.33 (p 0.188, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.33 (p 0.185, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.26 (p 0.302, n 18). could be the mix.
skeptic: leave-one-out range -0.39 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.188, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for FGF2 in astrocytes.

case closed: nothing better to follow up.

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