Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in proximal tubule cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5243
Sealed predictions
- FAM20C in dopamine neurons, braak-0.16 (p 0.685) → -0.76 (p 0.016)receipt 5253
- FAM20C in oligodendrocytes, braak-0.52 (p 0.150) → -0.58 (p 0.102)receipt 5252
Swarm cases
receipt 5253: FAM20C in dopamine neurons, braak
- power
- full sample -0.49 (p 0.037, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.49 (p 0.040, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.70 (p 0.0011, n 18). not the mix.
- skeptic
- leave-one-out range -0.63 to -0.43, sign flips 0; without severely affected donors -0.49 (p 0.037, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FAM20C in dopamine neurons.
case closed: nothing better to follow up.
receipt 5252: FAM20C in oligodendrocytes, braak
- power
- full sample -0.46 (p 0.052, n 18), 95% CI -0.77 to +0.00. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.45 (p 0.063, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.45 (p 0.063, n 18). could be the mix.
- skeptic
- leave-one-out range -0.62 to -0.40, sign flips 0; without severely affected donors -0.46 (p 0.052, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FAM20C in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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