Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (pancreatic acinar cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 66 Parkinson's papers of 13,571 | 0.45 |
| pathways Reactome | 6 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 3970
Sealed predictions
- EPO in dopamine neurons, braak+0.05 (p 0.893) → -0.69 (p 0.038)receipt 3980
Swarm cases
receipt 3980: EPO in dopamine neurons, braak
- power
- full sample -0.36 (p 0.145, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range -0.49 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.145, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for EPO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts