Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | compounds already reach it: vandetanib | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 754 | 0.82 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4456
Sealed predictions
- EPHA4 in dopamine neurons, braak+0.63 (p 0.069) → +0.52 (p 0.153)receipt 4463
Swarm cases
receipt 4463: EPHA4 in dopamine neurons, braak
- power
- full sample +0.78 (p 1.3e-4, n 18), 95% CI +0.50 to +0.91. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.69 (p 0.0014, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.72 (p 8.2e-4, n 18). not the mix.
- skeptic
- leave-one-out range +0.76 to +0.85, sign flips 0; without severely affected donors +0.78 (p 1.3e-4, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for EPHA4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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