parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophil progenitors	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 294	0.82
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 6182

ENTPD1 in microglia, braak+0.03 (p 0.947) → +0.33 (p 0.386)receipt 6187
ENTPD1 in dopamine neurons, braak-0.13 (p 0.738) → -0.28 (p 0.464)receipt 6188

receipt 6188: ENTPD1 in dopamine neurons, braak

power: full sample -0.17 (p 0.504, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.615, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.465, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to -0.08, sign flips 0; without severely affected donors -0.17 (p 0.504, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ENTPD1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6187: ENTPD1 in microglia, braak

power: full sample +0.13 (p 0.603, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.08 (p 0.767, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.15 (p 0.544, n 18). could be the mix.
skeptic: leave-one-out range +0.02 to +0.31, sign flips 0; without severely affected donors +0.13 (p 0.603, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ENTPD1 in microglia.

case closed: nothing better to follow up.

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