Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.30 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket: edifoligide sodium | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 19 Parkinson's papers of 5,598 | 0.61 |
| pathways Reactome | 17 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 1252
Sealed predictions
- E2F1 in dopamine neurons, braak-0.43 (p 0.253) → -0.18 (p 0.644)receipt 1259
Swarm cases
receipt 1259: E2F1 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.28 (p 0.258, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.116, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for E2F1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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