Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.36 (overall 0.23) | 0.36 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket: lorecivivint | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 41 Parkinson's papers of 1,148 | 0.51 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1862
Sealed predictions
- DYRK1A in dopamine neurons, braak+0.14 (p 0.724) → +0.18 (p 0.646)receipt 1866
Swarm cases
receipt 1866: DYRK1A in dopamine neurons, braak
- power
- full sample +0.28 (p 0.258, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.33 (p 0.188, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.332, n 18). could be the mix.
- skeptic
- leave-one-out range +0.19 to +0.44, sign flips 0; without severely affected donors +0.28 (p 0.258, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DYRK1A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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