Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 54 | 0.82 |
| pathways Reactome | 13 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 8451
Sealed predictions
- DYNC1I1 in dopamine neurons, braak+0.34 (p 0.374) → +0.47 (p 0.199)receipt 8457
Swarm cases
receipt 8457: DYNC1I1 in dopamine neurons, braak
- power
- full sample +0.32 (p 0.191, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.32 (p 0.191, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.148, n 18). could be the mix.
- skeptic
- leave-one-out range +0.25 to +0.45, sign flips 0; without severely affected donors +0.32 (p 0.191, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DYNC1I1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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