Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.61 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (rod photoreceptor cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: trifluoperazine hydrochloride, levomepromazine, sarizotan +30 | 1.00 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 31 Parkinson's papers of 1,510 | 0.54 |
| pathways Reactome | 2 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 11452
Earlier readings: 2026-10-26 0.47; 2026-10-25 0.47; 2026-10-24 0.47; 2026-10-23 0.47.
Sealed predictions
- DRD4 in dopamine neurons, braakn/a → n/areceipt 0547
- DRD4 in dopamine neurons, resilience+0.20 (p 0.407) → +0.19 (p 0.602)receipt 0067
- DRD4 in dopamine neurons, braak+0.04 (p 0.825) → +0.04 (p 0.797)receipt 0066
Swarm cases
receipt 0547: DRD4 in dopamine neurons, braak
- cell type
- DRD4 is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DRD4 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0067: DRD4 in dopamine neurons, resilience
- power
- full sample +0.19 (p 0.344, n 55), 95% CI -0.08 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: +0.21 (p 0.283, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: +0.22 (p 0.256, n 55). could be the mix.
- skeptic
- leave-one-out range +0.11 to +0.26, sign flips 0; without severely affected donors +0.15 (p 0.463, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for DRD4 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0066: DRD4 in dopamine neurons, braak
- power
- full sample -0.02 (p 0.829, n 84), 95% CI -0.24 to +0.19. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: -0.03 (p 0.768, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: -0.08 (p 0.464, n 84). could be the mix.
- skeptic
- leave-one-out range -0.06 to +0.01, sign flips 4; without severely affected donors +0.03 (p 0.793, n 75). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DRD4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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