parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocyte progenitor cells (3310 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.50
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 213	0.82
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 9718

receipt 9725: DPP6 in dopamine neurons, braak

power: full sample +0.19 (p 0.460, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.15 (p 0.544, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
skeptic: leave-one-out range +0.09 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.460, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DPP6 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9724: DPP6 in oligodendrocytes, braak

power: full sample -0.16 (p 0.532, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.33 (p 0.182, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.265, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to -0.04, sign flips 0; without severely affected donors -0.16 (p 0.532, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DPP6 in oligodendrocytes.

case closed: nothing better to follow up.

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