Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 715 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11374
Sealed predictions
- DOT1L in dopamine neurons, braak-0.08 (p 0.840) → -0.69 (p 0.042)receipt 11381
Swarm cases
receipt 11381: DOT1L in dopamine neurons, braak
- power
- full sample -0.39 (p 0.111, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.032, n 18). not the mix.
- skeptic
- leave-one-out range -0.55 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.111, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DOT1L in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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