parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	a small-molecule pocket	0.50
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 404	0.82
pathways Reactome	7 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 9930

receipt 9938: DOCK2 in dopamine neurons, braak

power: full sample -0.19 (p 0.444, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.346, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.036, n 18). not the mix.
skeptic: leave-one-out range -0.33 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.444, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DOCK2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9937: DOCK2 in microglia, braak

power: full sample +0.14 (p 0.585, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.671, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.11 (p 0.671, n 18). could be the mix.
skeptic: leave-one-out range +0.01 to +0.23, sign flips 0; without severely affected donors +0.14 (p 0.585, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DOCK2 in microglia.

case closed: nothing better to follow up.

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