Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.53 (overall 0.33) | 0.53 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 23 Parkinson's papers of 208 | 0.58 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1028
Sealed predictions
- DNAJB6 in dopamine neurons, braak+0.03 (p 0.946) → -0.25 (p 0.523)receipt 1034
Swarm cases
receipt 1034: DNAJB6 in dopamine neurons, braak
- power
- full sample -0.09 (p 0.735, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.840, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.00 (p 0.997, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.03, sign flips 2; without severely affected donors -0.09 (p 0.735, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DNAJB6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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