Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (decidual stromal cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: dkn-01, bhq-880 | 0.81 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 19 Parkinson's papers of 3,628 | 0.61 |
| pathways Reactome | 4 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 8951
Sealed predictions
- DKK1 in dopamine neurons, braak-0.07 (p 0.855) → -0.14 (p 0.722)receipt 8959
Swarm cases
receipt 8959: DKK1 in dopamine neurons, braak
- power
- full sample -0.14 (p 0.567, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.482, n 18). could be the mix.
- skeptic
- leave-one-out range -0.26 to -0.03, sign flips 0; without severely affected donors -0.14 (p 0.567, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DKK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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