Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.14 (overall 0.47) | 0.14 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0276
Sealed predictions
- DHX15 in dopamine neurons, braak+0.57 (p 0.109) → +0.52 (p 0.151)receipt 0285
Swarm cases
receipt 0285: DHX15 in dopamine neurons, braak
- power
- full sample +0.45 (p 0.063, n 18), 95% CI -0.03 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.45 (p 0.063, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.031, n 18). not the mix.
- skeptic
- leave-one-out range +0.38 to +0.55, sign flips 0; without severely affected donors +0.45 (p 0.063, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DHX15 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts