Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (adrenal medulla cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: zamicastat | 0.90 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 1 stopped | 0.84 |
| literature PubMed | 76 Parkinson's papers of 3,454 | 0.43 |
| pathways Reactome | 1 pathway; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 4021
Sealed predictions
- DBH in dopamine neurons, braak-0.45 (p 0.219) → -0.18 (p 0.639)receipt 4027
Swarm cases
receipt 4027: DBH in dopamine neurons, braak
- power
- full sample -0.30 (p 0.225, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.225, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.148, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.21, sign flips 0; without severely affected donors -0.30 (p 0.225, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DBH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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