Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CYRIB

CYFIP related Rac1 interactor B

translation score 0.51, read 2026-10-21; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including microglia; strongest in neutrophils0.75
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 150.91
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 5039

Sealed predictions

  1. CYRIB in dopamine neurons, braakn/a → n/areceipt 5046
  2. CYRIB in microglia, braakn/a → n/areceipt 5045

Swarm cases

receipt 5046: CYRIB in dopamine neurons, braak

cell type
CYRIB is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYRIB in dopamine neurons.

case closed: nothing better to follow up.

receipt 5045: CYRIB in microglia, braak

cell type
CYRIB is not measured in microglia; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYRIB in microglia.

case closed: nothing better to follow up.

Receipts

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