Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 10 Parkinson's papers of 6,090 | 0.69 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8936
Sealed predictions
- CYP2C9 in dopamine neurons, braak+0.61 (p 0.078) → +0.35 (p 0.361)receipt 8943
Swarm cases
receipt 8943: CYP2C9 in dopamine neurons, braak
- power
- full sample +0.43 (p 0.077, n 18), 95% CI -0.05 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.39 (p 0.111, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.164, n 18). could be the mix.
- skeptic
- leave-one-out range +0.34 to +0.50, sign flips 0; without severely affected donors +0.43 (p 0.077, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CYP2C9 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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