Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in hepatocytes | 0.75 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 17 Parkinson's papers of 1,028 | 0.62 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5948
Sealed predictions
- CYP27A1 in oligodendrocytes, braak+0.21 (p 0.588) → +0.49 (p 0.186)receipt 5987
- CYP27A1 in dopamine neurons, braak-0.50 (p 0.172) → +0.38 (p 0.311)receipt 5988
Swarm cases
receipt 5988: CYP27A1 in dopamine neurons, braak
- power
- full sample -0.07 (p 0.781, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.633, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.627, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.03, sign flips 4; without severely affected donors -0.07 (p 0.781, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CYP27A1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5987: CYP27A1 in oligodendrocytes, braak
- power
- full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.915, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.05 (p 0.840, n 18). could be the mix.
- skeptic
- leave-one-out range -0.06 to +0.15, sign flips 4; without severely affected donors +0.04 (p 0.861, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CYP27A1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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