Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: abx-il8, adakitug | 0.81 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 1 stopped | 0.80 |
| literature PubMed | 20 Parkinson's papers of 6,077 | 0.60 |
| pathways Reactome | 8 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 2893
Sealed predictions
- CXCL8 in dopamine neurons, braak-0.04 (p 0.912) → +0.63 (p 0.071)receipt 2901
Swarm cases
receipt 2901: CXCL8 in dopamine neurons, braak
- power
- full sample +0.30 (p 0.221, n 18), 95% CI -0.19 to +0.67. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.561, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.384, n 18). could be the mix.
- skeptic
- leave-one-out range +0.23 to +0.39, sign flips 0; without severely affected donors +0.30 (p 0.221, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CXCL8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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