parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enriched in microglia (937 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	64 Parkinson's papers of 3,931	0.45
pathways Reactome	5 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 5384

CX3CR1 in microglia, braak+0.32 (p 0.402) → +0.69 (p 0.039)receipt 5391
CX3CR1 in dopamine neurons, braak+0.16 (p 0.685) → -0.05 (p 0.893)receipt 5392

receipt 5392: CX3CR1 in dopamine neurons, braak

power: full sample -0.03 (p 0.901, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.861, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.00 (p 0.990, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.09, sign flips 4; without severely affected donors -0.03 (p 0.901, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CX3CR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5391: CX3CR1 in microglia, braak

power: full sample +0.37 (p 0.127, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.37 (p 0.127, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.54 (p 0.022, n 18). not the mix.
skeptic: leave-one-out range +0.30 to +0.47, sign flips 0; without severely affected donors +0.37 (p 0.127, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CX3CR1 in microglia.

case closed: nothing better to follow up.

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