Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CTRL

chymotrypsin like

translation score 0.40, read 2026-10-21; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including astrocytes; strongest in cardiomyocytes0.75
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
1130 Parkinson's trials, 8 stopped0.87
literature
PubMed
58 Parkinson's papers of 4,4120.46
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 4933

Sealed predictions

  1. CTRL in dopamine neurons, braakn/a → n/areceipt 4941
  2. CTRL in astrocytes, braakn/a → n/areceipt 4940

Swarm cases

receipt 4941: CTRL in dopamine neurons, braak

cell type
CTRL is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CTRL in dopamine neurons.

case closed: nothing better to follow up.

receipt 4940: CTRL in astrocytes, braak

cell type
CTRL is not measured in astrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CTRL in astrocytes.

case closed: nothing better to follow up.

Receipts

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