Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (endometrial secretory cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 1 stopped | 0.84 |
| literature PubMed | 2 Parkinson's papers of 489 | 0.85 |
| pathways Reactome | 5 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 6092
Sealed predictions
- CSF3 in dopamine neurons, braak-0.62 (p 0.078) → -0.47 (p 0.201)receipt 6099
Swarm cases
receipt 6099: CSF3 in dopamine neurons, braak
- power
- full sample -0.48 (p 0.044, n 18), 95% CI -0.77 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.45 (p 0.062, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.67 (p 0.0022, n 18). not the mix.
- skeptic
- leave-one-out range -0.61 to -0.41, sign flips 0; without severely affected donors -0.48 (p 0.044, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CSF3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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