Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.07 (overall 0.04) | 0.07 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (pericytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 74 | 0.91 |
| pathways Reactome | 4 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 5719
Sealed predictions
- COX4I2 in dopamine neurons, braak-0.05 (p 0.893) → -0.28 (p 0.464)receipt 5726
Swarm cases
receipt 5726: COX4I2 in dopamine neurons, braak
- power
- full sample -0.32 (p 0.194, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.289, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.114, n 18). could be the mix.
- skeptic
- leave-one-out range -0.50 to -0.24, sign flips 0; without severely affected donors -0.32 (p 0.194, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COX4I2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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