Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CORT

cortistatin

translation score 0.48, read 2026-10-27; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced in brain inhibitory neurons (16 nCPM)1.00
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
1 Parkinson's trial, 0 stopped1.00
literature
PubMed
18 Parkinson's papers of 4,6940.61
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 11425

Sealed predictions

  1. CORT in dopamine neurons, braakn/a → n/areceipt 11431

Swarm cases

receipt 11431: CORT in dopamine neurons, braak

cell type
CORT is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CORT in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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