Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.63 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: nebicapone, tolcapone, opicapone +1 | 1.00 |
| trials ClinicalTrials.gov | 80 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 906 Parkinson's papers of 6,396: well-trodden | 0.10 |
| pathways Reactome | 4 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 11448
Earlier readings: 2026-10-26 0.43; 2026-10-25 0.43; 2026-10-24 0.43; 2026-10-23 0.43.
Sealed predictions
- COMT in dopamine neurons, braak+0.11 (p 0.775) → -0.05 (p 0.907)receipt 0536
- COMT in dopamine neurons, braak+0.15 (p 0.346) → +0.01 (p 0.967)receipt 0047
- COMT in dopamine neurons, resilience-0.12 (p 0.654) → -0.07 (p 0.803)receipt 0048
Swarm cases
receipt 0536: COMT in dopamine neurons, braak
- power
- full sample -0.06 (p 0.807, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.621, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.09 (p 0.715, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.08, sign flips 1; without severely affected donors -0.06 (p 0.807, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COMT in dopamine neurons.
case closed: nothing better to follow up.
receipt 0048: COMT in dopamine neurons, resilience
- power
- full sample -0.09 (p 0.659, n 55), 95% CI -0.34 to +0.18. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: -0.11 (p 0.570, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.10 (p 0.599, n 55). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.00, sign flips 2; without severely affected donors -0.08 (p 0.690, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for COMT in dopamine neurons.
case closed: nothing better to follow up.
receipt 0047: COMT in dopamine neurons, braak
- power
- full sample +0.11 (p 0.331, n 84), 95% CI -0.11 to +0.31. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: +0.11 (p 0.310, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: +0.01 (p 0.931, n 84). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.14, sign flips 0; without severely affected donors +0.12 (p 0.299, n 75). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COMT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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