Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket: collagenase clostridium histolyticum, ocriplasmin | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 7,565 | 0.76 |
| pathways Reactome | 27 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 8257
Sealed predictions
- COL1A1 in dopamine neurons, braak-0.40 (p 0.285) → -0.55 (p 0.128)receipt 8266
Swarm cases
receipt 8266: COL1A1 in dopamine neurons, braak
- power
- full sample -0.50 (p 0.034, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.52 (p 0.026, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.60 (p 0.0080, n 18). not the mix.
- skeptic
- leave-one-out range -0.61 to -0.44, sign flips 0; without severely affected donors -0.50 (p 0.034, n 18). robust.
- cell type
- strongest in microglia: -0.76 (p 2.9e-4, n 18) vs -0.50 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COL1A1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up COL1A1 · microglia · braak: substantia nigra, an independent cohort: not measured
Receipts
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