Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 79 Parkinson's trials, 3 stopped | 0.95 |
| literature PubMed | 299 Parkinson's papers of 57,283 | 0.25 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 9285
Sealed predictions
- COIL in dopamine neurons, braak-0.13 (p 0.732) → +0.70 (p 0.035)receipt 9292
Swarm cases
receipt 9292: COIL in dopamine neurons, braak
- power
- full sample +0.29 (p 0.243, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.30 (p 0.232, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.27 (p 0.285, n 18). could be the mix.
- skeptic
- leave-one-out range +0.21 to +0.41, sign flips 0; without severely affected donors +0.29 (p 0.243, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for COIL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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