parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enriched in oligodendrocytes (427 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 115	0.82
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 5043

receipt 5051: CNTN2 in dopamine neurons, braak

power: full sample +0.09 (p 0.722, n 18), 95% CI -0.39 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.08 (p 0.767, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.10 (p 0.690, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.23, sign flips 1; without severely affected donors +0.09 (p 0.722, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CNTN2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5050: CNTN2 in oligodendrocytes, braak

power: full sample -0.23 (p 0.360, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.19 (p 0.439, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.20 (p 0.418, n 18). could be the mix.
skeptic: leave-one-out range -0.35 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.360, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CNTN2 in oligodendrocytes.

case closed: nothing better to follow up.

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