Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CMA1

chymase 1

translation score 0.48, read 2026-10-26; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enriched outside the brain (mast cells)0.10
chemistry
Open Targets
compounds already reach it: fulacimstat0.90
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 1260.91
pathways
Reactome
3 pathways; mostly growth signalling0.60

No case: the score is under the bar. Receipt 10569

Sealed predictions

  1. CMA1 in dopamine neurons, braakn/a → n/areceipt 10577

Swarm cases

receipt 10577: CMA1 in dopamine neurons, braak

cell type
CMA1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CMA1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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