Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in monocyte progenitors | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 47 Parkinson's trials, 4 stopped | 0.93 |
| literature PubMed | 1,172 Parkinson's papers of 6,863: well-trodden | 0.07 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3425
Sealed predictions
- CIT in dopamine neurons, braak+0.53 (p 0.146) → -0.09 (p 0.821)receipt 3432
Swarm cases
receipt 3432: CIT in dopamine neurons, braak
- power
- full sample +0.30 (p 0.225, n 18), 95% CI -0.19 to +0.67. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.32 (p 0.201, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.201, n 18). could be the mix.
- skeptic
- leave-one-out range +0.23 to +0.46, sign flips 0; without severely affected donors +0.30 (p 0.225, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CIT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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