Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.47 (overall 0.30) | 0.47 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 11 Parkinson's papers of 146 | 0.67 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1299
Sealed predictions
- CISD1 in dopamine neurons, braak+0.52 (p 0.148) → +0.63 (p 0.068)receipt 1307
Swarm cases
receipt 1307: CISD1 in dopamine neurons, braak
- power
- full sample +0.60 (p 0.0086, n 18), 95% CI +0.18 to +0.83. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.61 (p 0.0072, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.64 (p 0.0045, n 18). not the mix.
- skeptic
- leave-one-out range +0.54 to +0.69, sign flips 0; without severely affected donors +0.60 (p 0.0086, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CISD1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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