Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in schwann cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11602
Sealed predictions
- CHST3 in dopamine neurons, braak-0.44 (p 0.238) → +0.09 (p 0.821)receipt 11610
- CHST3 in oligodendrocytes, braak-0.32 (p 0.400) → -0.61 (p 0.084)receipt 11609
Swarm cases
receipt 11610: CHST3 in dopamine neurons, braak
- power
- full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.310, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.374, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHST3 in dopamine neurons.
case closed: nothing better to follow up.
receipt 11609: CHST3 in oligodendrocytes, braak
- power
- full sample -0.50 (p 0.035, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.53 (p 0.025, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.51 (p 0.030, n 18). not the mix.
- skeptic
- leave-one-out range -0.63 to -0.44, sign flips 0; without severely affected donors -0.50 (p 0.035, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHST3 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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