Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.25 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including other brain neurons; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | compounds already reach it: bnc-210, tc-6987, azd0328 +13 | 0.90 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 1 stopped | 0.20 |
| literature PubMed | 11 Parkinson's papers of 478 | 0.67 |
| pathways Reactome | 1 pathway; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 1726
Sealed predictions
- CHRNA7 in dopamine neurons, braak+0.14 (p 0.722) → +0.27 (p 0.487)receipt 1732
Swarm cases
receipt 1732: CHRNA7 in dopamine neurons, braak
- power
- full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.439, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.360, n 18). could be the mix.
- skeptic
- leave-one-out range +0.10 to +0.34, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHRNA7 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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