Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CHRM4

cholinergic receptor muscarinic 4

translation score 0.44, read 2026-10-19; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.09 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (goblet cells)0.10
chemistry
Open Targets
compounds already reach it: darotropium, terodiline hydrochloride, sofpironium bromide +71.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
3 Parkinson's papers of 710.82
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 2874

Sealed predictions

  1. CHRM4 in dopamine neurons, braakn/a → n/areceipt 2882

Swarm cases

receipt 2882: CHRM4 in dopamine neurons, braak

cell type
CHRM4 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CHRM4 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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